Quintara Discovery

Buffer Stability

Drug candidates can be instable in various physiologically-relevant buffers, such as simulated interstinal fluid or simulated gastric fluid. The stability in SIF or SGF may provide insightful information for understanding the PK behavior of the compounds. ContactUs

Buffer Stability Assays: Standard Assay Conditions (Customizable)

Compound Concentration 20 µM
Time Points Time points (0, 15, 30, 60 minutes) for half-life determinations; zero and 60 minutes for %disappearance of parent compound
Detection Method LC-MS/MS
Control compounds Omeprazole
Buffers Fasted or fed simulated intestinal/gastric fluids, with and without enyzmes pancreatin/pepsin
Deliverables %disappearance of parent compound, Half-life (t1/2)
Turnaround Time 2-3 Days
Compound requirements 20 μL 10 mM DMSO stock