Compound Concentration |
1 µM |
Hepatocyte density |
500,000 cells/mL |
Time Points |
Time points (0, 60, 120, 180 minutes) for half-life and intrinsic clearance determinations; zero and 60 minutes for %disappearance of parent compound
|
Detection Method |
LC-MS/MS |
Control compounds |
Midazolam |
Species |
Human, rat, mouse, dog and monkey (additional species are available on request) |
Deliverables |
%disappearance of parent compound, Half-life (t1/2) and intrinsic clearance (CLint)
|
Turnaround Time |
2-3 Days |
Compound requirements |
20 μL 10 mM DMSO stock |
|