Quintara Discovery

Plasma/Blood Stability

Plasma and blood contain esterases and proteases activities. Compounds with ester and amide bonds, such as many pro-drugs and peptide-based compounds, should be routinely tested for plasma/blood stability. ContactUs

Plasma/Blood Stability Assays: Standard Assay Conditions (Customizable)

Compound Concentration 1 µM
Time Points Time points (0, 60, 120, 240 minutes) for half-life determinations; zero and 240 minutes for %disappearance of parent compound
Detection Method LC-MS/MS
Control compounds Verapamil and Propantheline
Species Human, rat, mouse, dog and monkey (additional species are available on request)
Deliverables %disappearance of parent compound, Half-life (t1/2)
Turnaround Time 2-3 Days
Compound requirements 20 μL 10 mM DMSO stock