Quintara Discovery

Log D

LogD denotes the partition co-efficient of drug candidates in a lipophilic phase such as octanol and a hydrophilic phase like water.

The LogD value is valuable to predict many ADME properties such as solubility in buffers and gut, cellular permeability, the ability to penetrate the blood-brain barrier and the uptake into the intestine.

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Assay Methodology

Test compounds are mixed with octanol and phosphate buffer. The relative drug concentrations in each phase is determined by LC-MS and the LogD is calculated.